We used a myeloid-specific Mll1 knockout ( Mll1 f/fLyz2 Cre+) to determine the function of MLL1 in wound healing. Thus, we hypothesized that MLL1 influences macrophage-mediated inflammation in wound repair. Mixed-lineage leukemia-1 (MLL1) has been shown to direct gene expression by regulating nuclear factor-κB (NF-κB)–mediated inflammatory gene transcription. In diabetes, macrophages display a prolonged inflammatory phenotype in late wound healing. Macrophages are critical for the initiation and resolution of the inflammatory phase of wound repair.
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